Colonic mucosal prostaglandin E2 and cyclooxygenase expression before and after low aspirin doses in subjects at high risk or at normal risk for colorectal cancer.

@article{Krishnan2001ColonicMP,
  title={Colonic mucosal prostaglandin E2 and cyclooxygenase expression before and after low aspirin doses in subjects at high risk or at normal risk for colorectal cancer.},
  author={Koyamangalath Krishnan and Mack T Ruffin and Daniel P Normolle and Imad Shureiqi and Kashif Burney and Jo Ann Bailey and Marc Peters-Golden and Cheryl L Rock and Clement Richard Boland and Dean E. Brenner},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2001},
  volume={10 5},
  pages={
          447-53
        }
}
UNLABELLED Development of potential cancer chemopreventive drugs involves the systematic evaluation of these drugs in preliminary Phase I and II studies in human beings to identify the optimal drug dose, drug toxicity, and surrogate end point biomarker modulation. OBJECTIVES We tested the hypothesis that aspirin, at a single, once-daily 81-mg dose, will reduce colonic mucosal concentration of prostaglandin estradiol (E2) in individuals at high risk for colorectal cancer development similar to… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 56 REFERENCES

Linear and Nonlinear Models for the Analysis of Repeated Measurements

E. Vonesh, Chinchilli, V. eds
  • 1996
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Effect of aspirin on prostaglandin E2 formation and transforming growth factor alpha expression in human rectal mucosa from individuals with a history of adenomatous polyps of the colon.

  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 1999
VIEW 1 EXCERPT

Lipoxygenase inhibitors as potential cancer chemopreventives.

  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 1999