Colonic mucosal gene expression and genotype in irritable bowel syndrome patients with normal or elevated fecal bile acid excretion.

@article{Camilleri2015ColonicMG,
  title={Colonic mucosal gene expression and genotype in irritable bowel syndrome patients with normal or elevated fecal bile acid excretion.},
  author={Michael Camilleri and Paula J. Carlson and Andr{\'e}s Rosales Acosta and Irene A Busciglio},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2015},
  volume={309 1},
  pages={G10-20}
}
The mucosal gene expression in rectosigmoid mucosa (RSM) in irritable bowel syndrome with diarrhea (IBS-D) is unknown. Our objectives were, first, to study mRNA expression [by RT(2) PCR of 19 genes pertaining to tight junctions, immune activation, intestinal ion transport and bile acid (BA) homeostasis] in RSM in IBS-D patients (n = 47) and healthy controls (n = 17) and study expression of a selected protein (PDZD3) in 10 IBS-D patients and 4 healthy controls; second, to assess RSM mRNA… CONTINUE READING
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