Colonic metaplasia in the ileal pouch is associated with inflammation and is not the result of long-term adaptation

@article{Fruin2003ColonicMI,
  title={Colonic metaplasia in the ileal pouch is associated with inflammation and is not the result of long-term adaptation},
  author={A. Brent Fruin and Ola El- Zammer and Arthur F. Stucchi and M.P.H. Michael O’Brien and James M. Becker},
  journal={Journal of Gastrointestinal Surgery},
  year={2003},
  volume={7},
  pages={246-254}
}
Ileal pouch-anal anastomosis (IPAA) is the preferred surgical therapy for chronic ulcerative colitis (CUC) and familial adenomatous polyposis (FAP). Previous studies have demonstrated morphologic changes in pouch mucosa such as villous atrophy and crypt hyperplasia. These changes have been labeled “colonic metaplasia.” The aims of this study were to determine whether these changes represent “normal” long-term adaptation of the nondiseased pouch or instead are present only in the setting of… CONTINUE READING

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