Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis.

@article{Krajina2003ColonicLP,
  title={Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis.},
  author={Tamara Krajina and Frank Leithaeuser and Peter L Moeller and Zlatko Trobonjaca and J. Reimann},
  journal={European journal of immunology},
  year={2003},
  volume={33 4},
  pages={1073-83}
}
CD11c(+) (F4/80(-) CD68(-)) dendritic cells (DC) in the colonic lamina propria (cLP) of normal and immunodeficient (RAG1(-/-)) C57BL/6 (B6) mice show high surface expression of MHC class I/II molecules and CD1d, and low surface expression of CD40, CD80, CD86 costimulator molecules. CD4(+) alpha beta T cells from normal or MHC class II-deficient B6 mice transferred into congenic RAG1(-/-) hosts induce a progressive, lethal colitis. Concomitant with colitis development, DC in the inflamed cLP… CONTINUE READING
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