Colonic intra-epithelial carcinoma occurring in a hyperplastic polyp via a serrated adenoma.

Abstract

We present a case of intra-epithelial carcinoma occurring in a serrated adenoma of the colon. The pedunculated polyp, which measured 12 x 10 x 6 mm, was endoscopically removed from the ascending colon of a 78-year-old woman. Histologically, the polyp mainly consisted of serrated adenomatous glands, and had foci of intra-epithelial carcinoma at the top. Hyperplastic (metaplastic) areas were also present in both borders between the serrated adenomatous area and the surrounding normal mucosa. A sequential increase in the degree of dysplasia, and in the number of nuclei positively reactive for Ki-67 and p53 was evident from the hyperplastic areas toward the foci of carcinoma. The polyp described here may represent a carcinogenic potential of hyperplastic polyp via serrated adenoma.

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@article{Tanaka2001ColonicIC, title={Colonic intra-epithelial carcinoma occurring in a hyperplastic polyp via a serrated adenoma.}, author={Masashi Tanaka and Tomomi Kusumi and Yu Sasaki and Kazuo Yamagata and H Ichinohe and Junichi Nishida and Hajime Kudo}, journal={Pathology international}, year={2001}, volume={51 3}, pages={215-20} }