Colonic immune cells in irritable bowel syndrome: A systematic review and meta‐analysis

@article{Bashashati2018ColonicIC,
  title={Colonic immune cells in irritable bowel syndrome: A systematic review and meta‐analysis},
  author={Mohammad Bashashati and Shirin Moossavi and Cesare Cremon and Maria Raffaella Barbaro and S. Moraveji and Geoffrey A. Talmon and Nima Rezaei and Patrick A Hughes and Z X Bian and C. H. Choi and Oh Young Lee and Mo{\"i}se Co{\"e}ffier and L. Chang and Lena Ohman and Max J Schmulson and Richard W. McCallum and Magnus Simr{\'e}n and Keith A. Sharkey and Giovanni Barbara},
  journal={Neurogastroenterology \& Motility},
  year={2018},
  volume={30}
}
Increases in mucosal immune cells have frequently been observed in irritable bowel syndrome (IBS) patients. However, this finding is not completely consistent between studies, possibly due to a combination of methodological variability, population differences and small sample sizes. We performed a meta‐analysis of case–control studies that compared immune cell counts in colonic biopsies of IBS patients and controls. 

Mast cells are increased in the small intestinal mucosa of patients with irritable bowel syndrome: A systematic review and meta‐analysis

Colonic mast cells have been proposed to be related to the pathophysiology of irritable bowel syndrome (IBS). Whether mast cell counts are altered in the small intestine, a less‐explored region in

Expression of immune‐related genes in rectum and colon descendens of Irritable Bowel Syndrome patients is unrelated to clinical symptoms

Evaluation of the gene expression of a large set of immune‐related genes in mucosal biopsies from IBS patients and healthy volunteers (HV) finds positive results for several immune-related genes.

Irritable bowel syndrome is strongly associated with the primary and idiopathic mast cell disorders

This association between IBS and mast cell disorders (MCDs) has not been studied and was examined using two large databases and verified with manual chart review.

Colonic mast cell numbers, symptom profile, and mucosal expression of elements of the epithelial barrier in irritable bowel syndrome

  • J. SundinS. Nordlander L. Öhman
  • Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2019
This study aimed to determine whether patients with IBS displayed altered mucosal mast cell (MC) numbers and proportions of MCs co‐localizing with nerves compared with healthy subjects (HS) and

The Emerging Role of Mast Cells in Irritable Bowel Syndrome.

IBS is actually a collection of diseases that present themselves with a similar clinical that has recently seen an increase in interest due to the introduction of the low–fermentable oligo-, di-, and monosaccharide and polyol (FODMAP) diet.

Immune responses in the irritable bowel syndromes: time to consider the small intestine

The current literature suggests the pathogenesis of IBS is not limited to the colon but rather may involve dysfunction of the entire intestinal tract, and reports of localised food hypersensitivity responses in IBS patients implicate the small intestine as the site of immune-microbial-food interactions.

Randomised clinical trial and meta‐analysis: mesalazine treatment in irritable bowel syndrome—effects on gastrointestinal symptoms and rectal biomarkers of immune activity

Low‐grade immune activation in the gut is a potential treatment target in irritable bowel syndrome (IBS) and should be considered as a treatment target for patients with IBS.

Immune activation in irritable bowel syndrome: what is the evidence?

How immune mediators, particularly those released by mast cells, can directly activate or sensitize pain-transmitting nerves, leading to increased pain signalling and abdominal pain is described.

Ileocolonic Histopathological and Microbial Alterations in the Irritable Bowel Syndrome: A Nested Community Case-Control Study

A modest but significant increase in IELs was observed in IBS vs. controls in a population-based setting, and Subtle TI and cecal inflammation may play a pathogenic role in Ibs but needs confirmation.
...

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...