Colonic immune cells in irritable bowel syndrome: A systematic review and meta‐analysis

  title={Colonic immune cells in irritable bowel syndrome: A systematic review and meta‐analysis},
  author={Mohammad Bashashati and Shirin Moossavi and Cesare Cremon and Maria Raffaella Barbaro and S. Moraveji and Geoffrey A. Talmon and Nima Rezaei and Patrick A Hughes and Z X Bian and C. H. Choi and Oh Young Lee and Mo{\"i}se Co{\"e}ffier and L. Chang and Lena Ohman and Max J Schmulson and Richard W. McCallum and Magnus Simr{\'e}n and Keith A. Sharkey and Giovanni Barbara},
  journal={Neurogastroenterology \& Motility},
Increases in mucosal immune cells have frequently been observed in irritable bowel syndrome (IBS) patients. However, this finding is not completely consistent between studies, possibly due to a combination of methodological variability, population differences and small sample sizes. We performed a meta‐analysis of case–control studies that compared immune cell counts in colonic biopsies of IBS patients and controls. 

Mast cells are increased in the small intestinal mucosa of patients with irritable bowel syndrome: A systematic review and meta‐analysis

Colonic mast cells have been proposed to be related to the pathophysiology of irritable bowel syndrome (IBS). Whether mast cell counts are altered in the small intestine, a less‐explored region in

Expression of immune‐related genes in rectum and colon descendens of Irritable Bowel Syndrome patients is unrelated to clinical symptoms

Evaluation of the gene expression of a large set of immune‐related genes in mucosal biopsies from IBS patients and healthy volunteers (HV) finds positive results for several immune-related genes.

Irritable bowel syndrome is strongly associated with the primary and idiopathic mast cell disorders

This association between IBS and mast cell disorders (MCDs) has not been studied and was examined using two large databases and verified with manual chart review.

Colonic mast cell numbers, symptom profile, and mucosal expression of elements of the epithelial barrier in irritable bowel syndrome

  • J. SundinS. Nordlander L. Öhman
  • Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2019
This study aimed to determine whether patients with IBS displayed altered mucosal mast cell (MC) numbers and proportions of MCs co‐localizing with nerves compared with healthy subjects (HS) and

The Emerging Role of Mast Cells in Irritable Bowel Syndrome.

IBS is actually a collection of diseases that present themselves with a similar clinical that has recently seen an increase in interest due to the introduction of the low–fermentable oligo-, di-, and monosaccharide and polyol (FODMAP) diet.

Immune responses in the irritable bowel syndromes: time to consider the small intestine

The current literature suggests the pathogenesis of IBS is not limited to the colon but rather may involve dysfunction of the entire intestinal tract, and reports of localised food hypersensitivity responses in IBS patients implicate the small intestine as the site of immune-microbial-food interactions.

Randomised clinical trial and meta‐analysis: mesalazine treatment in irritable bowel syndrome—effects on gastrointestinal symptoms and rectal biomarkers of immune activity

Low‐grade immune activation in the gut is a potential treatment target in irritable bowel syndrome (IBS) and should be considered as a treatment target for patients with IBS.

Immune activation in irritable bowel syndrome: what is the evidence?

How immune mediators, particularly those released by mast cells, can directly activate or sensitize pain-transmitting nerves, leading to increased pain signalling and abdominal pain is described.

Ileocolonic Histopathological and Microbial Alterations in the Irritable Bowel Syndrome: A Nested Community Case-Control Study

A modest but significant increase in IELs was observed in IBS vs. controls in a population-based setting, and Subtle TI and cecal inflammation may play a pathogenic role in Ibs but needs confirmation.



Cytokine imbalance in irritable bowel syndrome: a systematic review and meta‐analysis

  • M. BashashatiN. Rezaei M. Simrén
  • Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2014
A recent meta‐analysis showed correlations between cytokine [interleukin‐10 (IL‐10) and tumor necrosis factor (TNF)] gene polymorphisms and IBS; however, it is still unknown whether patients with IBS have different cytokine profiles compared to healthy population.

Mucosal mast cell counts correlate with visceral hypersensitivity in patients with diarrhea predominant irritable bowel syndrome

Whether a relationship exists between the number of mucosal mast cells in the gut and visceral hypersensitivity in irritable bowel syndrome is determined.

Mucosal Immune Activation in Irritable Bowel Syndrome: Gender-Dependence and Association With Digestive Symptoms

A large subset of IBS patients shows gender-dependent mucosal infiltration of immunocytes that correlates with abdominal bloating and dysmotility-like dyspepsia, and provides the rationale for considering immune mechanisms as a pathophysiological component in a subset ofIBS patients.

Immune Activation in Irritable Bowel Syndrome: Can Neuroimmune Interactions Explain Symptoms?

Identifying what the key changes in the GI immune system are in IBS and how these changes modulate viscerosensory nervous function is essential for the development of novel therapies for the underlying disorder.

Neuroimmune interactions at different intestinal sites are related to abdominal pain symptoms in children with IBS

  • G. Di NardoG. Barbara L. Stronati
  • Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2014
In children with IBS and healthy controls, ileocolonic mast cell infiltration and fecal calprotectin are measured and the relationships between these parameters and abdominal pain symptoms and stooling pattern are evaluated.

Colonic mucosal mediators from patients with irritable bowel syndrome excite enteric cholinergic motor neurons

  • B. BalestraR. Vicini G. Barbara
  • Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2012
This data indicates that suppression of mucosal mediators in the mucosal milieu contributes to visceral hypersensitivity and abdominal pain in patients with irritable bowel syndrome and their impact on myenteric neurons is uncertain.

Mucosal Immune Cell Numbers and Visceral Sensitivity in Patients With Irritable Bowel Syndrome: Is There Any Relationship?

Although the number of mast cells, macrophages, T cells, and λFLC-positive mast cells is decreased in IBS compared with HV, this is not associated with the presence of visceral hypersensitivity or abnormal stress response.

A controlled study of colonic immune activity and beta7+ blood T lymphocytes in patients with irritable bowel syndrome.

Using human intestinal biopsies to study the pathogenesis of irritable bowel syndrome

Important changes have been discovered involving the enteric nervous system and the extrinsic sensory pathway (dorsal root ganglia neurons), the immune system, and epithelial signaling in IBS patients compared to healthy subjects.