Colonic healing: A role for polymorphonuclear leucocytes and oxygen radical production

@article{Shandall1986ColonicHA,
  title={Colonic healing: A role for polymorphonuclear leucocytes and oxygen radical production},
  author={Ahmed Abu-El-Futuh Shandall and G. T. Williams and Maurice B. Hallett and Howard L. Young},
  journal={British Journal of Surgery},
  year={1986},
  volume={73}
}
Using a model of ‘reperfusion injury’ as a mechanism of oxygen radical (OR) production in vivo, we have demonstrated that superoxide (O2‐) is the major source of damage. Inhibition of its production from polymorphonuclear leucocytes (PMNs) by aprotinin, a protease inhibitor, or by scavenging with superoxide dismutase (SOD), resulted in reduced oxidation of of tissue glutathione (P < 0.002). Colonic healing after anastomosis was also improved by aprotinin as measured by histology (P < 0.05… Expand
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