Colonic epithelial cell proliferation in hereditary non-polyposis colorectal cancer.

@article{Green1998ColonicEC,
  title={Colonic epithelial cell proliferation in hereditary non-polyposis colorectal cancer.},
  author={Steven E. Green and Peter Chapman and John Burn and Alastair D. Burt and Mark Bennett and D. R. Appleton and Jagmohan S Varma and John C. Mathers},
  journal={Gut},
  year={1998},
  volume={43 1},
  pages={85-92}
}
BACKGROUND Despite the recent discovery of four genes responsible for up to 90% of all cases of hereditary non-polyposis colorectal cancer (HNPCC), there will still be families in whom predictive testing is not possible. A phenotypic biomarker would therefore be useful. An upwards shift of the proliferative compartment in colonic crypts is reported to be one of the earliest changes in premalignant mucosa. AIMS To assess the role of crypt cell proliferation as a phenotypic biomarker in HNPCC… CONTINUE READING