Colonic epithelial cell mediated suppression of CD4 T cell activation.

@article{Cruickshank2004ColonicEC,
  title={Colonic epithelial cell mediated suppression of CD4 T cell activation.},
  author={Sheena Cruickshank and Laila D. McVay and Daniel C Baumgart and Peter John Felsburg and Simon R. Carding},
  journal={Gut},
  year={2004},
  volume={53 5},
  pages={678-84}
}
BACKGROUND AND AIMS As the first point of contact with enteric antigens, intestinal epithelial cells (IEC) may be key in regulating mucosal immune responses. We determined therefore if murine colonic epithelial cells (CEC) have tolerogenic or activating effects on CD4 T cells. METHODS Using a novel CEC, macrophages, and CD4 T cell coculture system, mitogen and antigen specific responses of naïve and antigen primed CD4 T cells were assessed. RESULTS Although a proportion of CEC express the… CONTINUE READING

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