Colonic epithelial cell activation and the paradoxical effects of butyrate.

@article{Gibson1999ColonicEC,
  title={Colonic epithelial cell activation and the paradoxical effects of butyrate.},
  author={Peter R. Gibson and Ourania Rosella and Andrew G. Wilson and John M. Mariadason and Kurt L. Rickard and Keith Byron and David Barkla},
  journal={Carcinogenesis},
  year={1999},
  volume={20 4},
  pages={539-44}
}
Butyrate may have paradoxical effects on epithelial cells of similar origin. This study aimed to examine the hypothesis that one mechanism that dictates a cell's response to butyrate is its state of activation. First, the responses to 24 h exposure to butyrate (1-2 mM) of normal and neoplastic human colonic epithelial cells activated by their isolation and primary culture, and of colon cancer cell lines, LIM1215 and Caco-2, were examined. In primary cultures of normal and cancer cells, butyrate… CONTINUE READING
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