Colonic delivery of compression coated nisin tablets using pectin/HPMC polymer mixture.

@article{Uurlu2007ColonicDO,
  title={Colonic delivery of compression coated nisin tablets using pectin/HPMC polymer mixture.},
  author={Timuçin Uğurlu and Murat Turkoğlu and Umran Soyogul Gurer and Burcak Gurbuz Akarsu},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2007},
  volume={67 1},
  pages={202-10}
}
Nisin containing pectin/HPMC compression coated tablets were prepared and their in vitro behavior tested for colonic delivery. Nisin is a 34-amino-acid residue long, heat stable peptide belonging to the group A lantibiotics with wide antimicrobial activity against Gram-positive bacteria. The invention can be useful for treating colonic infectious diseases such as by Clostridium difficile, and also by colonization of vancomycin-resistant enterococci. In this study, each 100mg core tablet of… CONTINUE READING

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