Colonic crypt cell proliferation state assessed by whole crypt microdissection in sporadic neoplasia and familial adenomatous polyposis.

@article{Mills2001ColonicCC,
  title={Colonic crypt cell proliferation state assessed by whole crypt microdissection in sporadic neoplasia and familial adenomatous polyposis.},
  author={Sarah J Mills and John C. Mathers and Pamela Chapman and John Burn and Andrew Gunn},
  journal={Gut},
  year={2001},
  volume={48 1},
  pages={41-6}
}
BACKGROUND It has yet to be established whether proliferative activity in the macroscopically normal colonic mucosa is causally correlated with neoplastic risk. Measurement of proliferative activity in human subjects is of necessity usually undertaken using indirect methods with inherent limitations, and relatively little has been published on the effect of normal biological variables on such indices. AIMS To establish the validity of mitosis counts following whole crypt microdissection as an… CONTINUE READING
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