Colonic Sulfide in Pathogenesis and Treatment of Ulcerative Colitis

@article{Roediger2004ColonicSI,
  title={Colonic Sulfide in Pathogenesis and Treatment of Ulcerative Colitis},
  author={William E. W. Roediger and J. Moore and Wendy J Babidge},
  journal={Digestive Diseases and Sciences},
  year={2004},
  volume={42},
  pages={1571-1579}
}
A role for colonic sulfide in the pathogenesisand treatment of ulcerative colitis (UC) has emergedbased on biochemical, microbiological, nutritional,toxicological, epidemiological, and therapeuticevidence. Metabolism of isolated colonic epithelial cellshas indicated that the bacterial short-chain fatty acidn-butyrate maintains the epithelial barrier and thatsulfides can inhibit oxidation of n-butyrate analogous to that observed in active UC. Sulfurfor fermentation in the colon is essential forn… Expand
Dietary Factors in Sulfur Metabolism and Pathogenesis of Ulcerative Colitis
TLDR
The increasing severity of inflammation along the proximal-to-distal axis in UC is due to the dilution of beneficial factors, concentration of toxic factors, and changing detoxification capacity of the host, all of which are intimately linked to the nutrient flow from the diet. Expand
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TLDR
A correlation between the presence of sulphate-reducing bacteria and an inflammatory response in UC sufferers is reinforced. Expand
Decreased mucosal sulfide detoxification is related to an impaired butyrate oxidation in ulcerative colitis
TLDR
An impaired detoxification mechanism of sulfide at TST protein and RNA level in UC was found andlammation was clearly associated with the observed TST deficiency. Expand
Evidence That Hydrogen Sulfide Is a Genotoxic Agent
TLDR
Chronic cytotoxicity of sulfide and genotoxicity using the single-cell gel electrophoresis (SCGE) in Chinese hamster ovary and HT29-Cl cells indicate that given a predisposing genetic background that compromises DNA repair, H2S may lead to genomic instability or the cumulative mutations found in adenomatous polyps leading to colorectal cancer. Expand
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TLDR
It is suggested here that a novel axis of research is to assess the effects of hydrogen sulfide in shaping colonic microbiome structure, and Generation of hydrogen sulphide via pathways other than dissimilatory sulfate reduction may be as, or more, important than those involving the SRB. Expand
Modulation of colonic hydrogen sulfide production by diet and mesalazine utilizing a novel gas-profiling technology
TLDR
Production of H2S is greatly enhanced by sulfur-amino acids but not inorganic sulfate, and is effectively suppressed by readily fermentable fibers, informing potential designs of dietary therapies to reduce H1N1 production in vivo. Expand
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TLDR
Standardized breath gas measurements combined with ever-improving molecular methodologies could provide novel strategies to prevent, diagnose or manage numerous colonic disorders. Expand
Gastrointestinal and Microbial Responses to Sulfate-Supplemented Drinking Water in Mice
TLDR
The effects of short-term and long-term inorganic sulfate supplementation of the drinking water on gastrointestinal sulfate and H2S concentrations, and the density of large intestinal sulfomucin-containing goblet cells, were examined in C3H/HeJBir mice. Expand
Adaptative metabolic response of human colonic epithelial cells to the adverse effects of the luminal compound sulfide.
TLDR
The results are compatible with a metabolic adaptative response of the HT-29 colonic epithelial cells to sulfide-induced O(2) consumption reduction which, through the maintenance of a constant energetic load and an increased mitochondrial proton leak, would participate in the preservation of cellular viability. Expand
Endogenous Hydrogen Sulfide Is an Anti-inflammatory Molecule in Dextran Sodium Sulfate-Induced Colitis in Mice
TLDR
The results indicated that the inhibition of endogenous H2S generation caused the deterioration of DSS-induced colitis, and it was concluded that physiological H 2S might act as an anti-inflammatory molecule in colitis. Expand
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