Colonic Sulfide in Pathogenesis and Treatment of Ulcerative Colitis

@article{Roediger2004ColonicSI,
  title={Colonic Sulfide in Pathogenesis and Treatment of Ulcerative Colitis},
  author={William E W Roediger and J W Moore and Wendy J Babidge},
  journal={Digestive Diseases and Sciences},
  year={2004},
  volume={42},
  pages={1571-1579}
}
A role for colonic sulfide in the pathogenesisand treatment of ulcerative colitis (UC) has emergedbased on biochemical, microbiological, nutritional,toxicological, epidemiological, and therapeuticevidence. Metabolism of isolated colonic epithelial cellshas indicated that the bacterial short-chain fatty acidn-butyrate maintains the epithelial barrier and thatsulfides can inhibit oxidation of n-butyrate analogous to that observed in active UC. Sulfurfor fermentation in the colon is essential forn… 
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TLDR
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Decreased mucosal sulfide detoxification is related to an impaired butyrate oxidation in ulcerative colitis
TLDR
An impaired detoxification mechanism of sulfide at TST protein and RNA level in UC was found andlammation was clearly associated with the observed TST deficiency.
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TLDR
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TLDR
It is suggested here that a novel axis of research is to assess the effects of hydrogen sulfide in shaping colonic microbiome structure, and Generation of hydrogen sulphide via pathways other than dissimilatory sulfate reduction may be as, or more, important than those involving the SRB.
Contributions of the microbial hydrogen economy to colonic homeostasis
TLDR
Standardized breath gas measurements combined with ever-improving molecular methodologies could provide novel strategies to prevent, diagnose or manage numerous colonic disorders.
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TLDR
Production of H2S is greatly enhanced by sulfur-amino acids but not inorganic sulfate, and is effectively suppressed by readily fermentable fibers, informing potential designs of dietary therapies to reduce H1N1 production in vivo.
Gastrointestinal and Microbial Responses to Sulfate-Supplemented Drinking Water in Mice
TLDR
The effects of short-term and long-term inorganic sulfate supplementation of the drinking water on gastrointestinal sulfate and H2S concentrations, and the density of large intestinal sulfomucin-containing goblet cells, were examined in C3H/HeJBir mice.
Endogenous Hydrogen Sulfide Is an Anti-inflammatory Molecule in Dextran Sodium Sulfate-Induced Colitis in Mice
TLDR
The results indicated that the inhibition of endogenous H2S generation caused the deterioration of DSS-induced colitis, and it was concluded that physiological H 2S might act as an anti-inflammatory molecule in colitis.
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TLDR
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