Colonic Mucosal Gene Expression and Genotype in Irritable Bowel Syndrome Patients 6 with Normal or Elevated Fecal Bile Acid Excretion

Abstract

48 The mucosal gene expression in rectosigmoid mucosa (RSM) in irritable bowel syndrome 49 with diarrhea (IBS-D) is unknown. Our objectives were: first, to study mRNA expression (by 50 RT PCR of 19 genes pertaining to tight junctions, immune activation, intestinal ion transport 51 and bile acid homeostasis) in RSM in IBS-D patients (n=47) and healthy… (More)

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