Colonic Luminal Hydrogen Sulfide Is Not Elevated in Ulcerative Colitis

  title={Colonic Luminal Hydrogen Sulfide Is Not Elevated in Ulcerative Colitis},
  author={J. Moore and Wendy J Babidge and Susan Millard and William E W Roediger},
  journal={Digestive Diseases and Sciences},
It has been proposed that the reduction inn-butyrate oxidation by colonic epithelial cellsobserved in ulcerative colitis may be related toexposure to reduced forms of sulfur derived fromdissimilatory sulfate reduction by luminal microflora. Thisstudy aims to compare stool sulfide concentrations incontrol and colitic subjects. Control subjects hadsignificant colorectal disease excluded by virtue of their selection. Patients with ulcerativecolitis were stratified by disease extent and activity… Expand
Decreased mucosal sulfide detoxification is related to an impaired butyrate oxidation in ulcerative colitis
An impaired detoxification mechanism of sulfide at TST protein and RNA level in UC was found andlammation was clearly associated with the observed TST deficiency. Expand
Association Between Fecal Hydrogen Sulfide Production and Pouchitis
The results provide a rationale for additional studies to determine whether the high sulfide production is a cause or effect of pouchitis, and suggest a fundamental difference in gut sulfide metabolism that could have implications for the etiology of ulcerative colitis as well as the pouchitis of patients with ulceratives colitis. Expand
Physiology of sulfide in the rat colon: use of bismuth to assess colonic sulfide production.
Bismuth subnitrate was utilized to quantitate intracolonic sulfide release based on observations that bismuth avidly binds sulfide; quantitatively releases bound sulfide when acidified; and 3) does not influence fecal sulfide production by fecal homogenates. Expand
Evidence That Hydrogen Sulfide Is a Genotoxic Agent
Chronic cytotoxicity of sulfide and genotoxicity using the single-cell gel electrophoresis (SCGE) in Chinese hamster ovary and HT29-Cl cells indicate that given a predisposing genetic background that compromises DNA repair, H2S may lead to genomic instability or the cumulative mutations found in adenomatous polyps leading to colorectal cancer. Expand
Hydrogen Sulfide and Colonic Epithelial Metabolism
Hydrogen sulfide (HS−) impairs the oxidation of butyrate in colonocytes and is found in excess in feces of patients with ulcerative colitis. The possible pathogenic role of HS− in ulcerative colitisExpand
Luminal sulfide and large intestine mucosa: friend or foe?
The concept that sulfide is simply a metabolic troublemaker toward colonic epithelial cells has been challenged by the discovery that micromolar concentration of H2S is able to increase the cell respiration and to energize mitochondria allowing these cells to detoxify and to recover energy from luminal sulfide. Expand
Contributions of the microbial hydrogen economy to colonic homeostasis
Standardized breath gas measurements combined with ever-improving molecular methodologies could provide novel strategies to prevent, diagnose or manage numerous colonic disorders. Expand
Influence of Feces from Patients with Ulcerative Colitis on Butyrate Oxidation in Rat Colonocytes
Feces from healthy subjects and patients with quiescent and active ulcerative colitis containhibitor(s) of the production of CO2 from butyrate oxidation in colonocytes, however, a specific inhibitory effect of feces from patients with ulceratives colitis on the productionof CO2 could not be identified. Expand
Dietary Factors in Sulfur Metabolism and Pathogenesis of Ulcerative Colitis
The increasing severity of inflammation along the proximal-to-distal axis in UC is due to the dilution of beneficial factors, concentration of toxic factors, and changing detoxification capacity of the host, all of which are intimately linked to the nutrient flow from the diet. Expand
Oxidation of hydrogen sulfide and methanethiol to thiosulfate by rat tissues: a specialized function of the colonic mucosa.
It is concluded that colonic mucosa possesses a specialized detoxification system that allows this tissue to rapidly metabolize H(2)S and CH(3)SH to thiosulfate, and Presumably, this highly developed system protects the colon from what otherwise might be injurious concentrations of H( 2)S or CH( 3)SH. Expand


Butyrate oxidation is impaired in the colonic mucosa of sufferers of quiescent ulcerative colitis.
Data confirm that in quiescent ulcerative colitis there is an impairment of butyrate oxidation, which is significantly impaired compared with that in normal mucosa. Expand
Reducing sulfur compounds of the colon impair colonocyte nutrition: implications for ulcerative colitis.
Metabolic effects of sodium hydrogen sulfide on butyrate oxidation along the length of the colon closely mirror metabolic abnormalities observed in active ulcerative colitis, and the increased production of sulfide in ulceratives colitis suggests that the action of mercaptides may be involved in the genesis of ulcerATIVE colitis. Expand
It is suggested that failure of fatty-acid (n-butyrate) oxidation in UC is an expression of an energy-deficiency disease of the colonic mucosa, especially the frequency of UC in the distal colon. Expand
Sulphide impairment of substrate oxidation in rat colonocytes: a biochemical basis for ulcerative colitis?
A hypothesis for the disease process of ulcerative colitis is that sulphides may form persulphides with butyryl-CoA, which would inhibit cellular short-chain acyl- CoA deHydrogenase and beta-oxidation to induce an energy-deficiency state in colonocytes and mucosal inflammation. Expand
Hydrogen sulphide and total acid-volatile sulphide in faeces, determined with a direct spectrophotometric method.
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A method for direct determination of sulphide in faecal homogenates, and techniques for collecting faeces to permit determination of both hydrogen sulphide and total sulphide, do not support previous claims that sulphidogenesis occurs only in non-methanogenic faece. Expand
Therapeutic benefits from a poorly absorbed prednisolone enema in distal colitis.
There are theoretical advantages in using a poorly absorbed enema to avoid the possibility of systemic steroid effects in patients requiring long term steroid treatment. Expand
Salicylate s inhibit bacterial sul® de production within the colonic lumen in ulcerative colitis
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