Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition.

Abstract

Nonsteroidal anti-inflammatory drugs (NSAID) display promising antineoplastic activity, but toxicity resulting from cyclooxygenase (COX) inhibition limits their clinical use for chemoprevention. Studies suggest that the mechanism may be COX independent, although alternative targets have not been well defined. Here, we show that the NSAID sulindac sulfide… (More)
DOI: 10.1158/1940-6207.CAPR-10-0030

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@article{Tinsley2010ColonTC, title={Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition.}, author={Heather Nicole Tinsley and Bernard Dewayne Gary and Jose T Thaiparambil and Nan Li and Wenyan Lu and Yonghe Li and Yulia Y. Maxuitenko and Adam B. Keeton and Gary Anthony Piazza}, journal={Cancer prevention research}, year={2010}, volume={3 10}, pages={1303-13} }