Colon-specific regulation of vitamin D hydroxylases--a possible approach for tumor prevention.

@article{Kllay2005ColonspecificRO,
  title={Colon-specific regulation of vitamin D hydroxylases--a possible approach for tumor prevention.},
  author={Enikoe K{\'a}llay and Giovanna Bises and Erika Bajna and Christian Bieglmayer and Waltraud Gerdenitsch and Ilse Steffan and Shigeaki Kato and Harvey James Armbrecht and Heide S. Cross},
  journal={Carcinogenesis},
  year={2005},
  volume={26 9},
  pages={1581-9}
}
Epidemiological data suggest a protective role of calcium and vitamin D against colorectal tumor pathogenesis. 1,25-dihydroxyvitamin D3 (1,25-D3) is a key determinant of calcium homeostasis, cell proliferation and differentiation. Calcium in the intestinal lumen functions as a growth regulator and may prevent cancer by direct reduction of colonocyte proliferation. While calcium or vitamin D can counteract proliferation by itself, they could also interact if nutritional calcium were to modulate… CONTINUE READING
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