Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism.

@article{Yan2011ColonspecificDO,
  title={Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism.},
  author={Fang Yan and Hanwei Cao and Timothy L Cover and M. Kay Washington and Yan Shi and Linshu Liu and Rupesh Chaturvedi and Richard M Peek and Keith T Wilson and David Brent Polk},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 6},
  pages={
          2242-53
        }
}
Probiotic bacteria can potentially have beneficial effects on the clinical course of several intestinal disorders, but our understanding of probiotic action is limited. We have identified a probiotic bacteria-derived soluble protein, p40, from Lactobacillus rhamnosus GG (LGG), which prevents cytokine-induced apoptosis in intestinal epithelial cells. In the current study, we analyzed the mechanisms by which p40 regulates cellular responses in intestinal epithelial cells and p40's effects on… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 56 REFERENCES

PI 3-kinase, Akt and cell survival.

  • Seminars in cell & developmental biology
  • 2004
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2010
VIEW 1 EXCERPT

Inf lammation in the intestinal tract: pathogenesis and treatment

RS Blumberg
  • Dig Dis
  • 2009
VIEW 1 EXCERPT