Colon-specific delivery of 5-aminosalicylic acid from chitosan-Ca-alginate microparticles.

  title={Colon-specific delivery of 5-aminosalicylic acid from chitosan-Ca-alginate microparticles.},
  author={Kristina Mladenovska and R. S. Raicki and Emilija I Janevik and Trpe Ristoski and Maja Jurhar Pavlova and Zoran Kavrakovski and Marija Glava{\vs} Dodov and Katerina Goracinova},
  journal={International journal of pharmaceutics},
  volume={342 1-2},
Chitosan-Ca-alginate microparticles for colon-specific delivery and controlled release of 5-aminosalicylic acid after peroral administration were prepared using spray drying method followed by ionotropic gelation/polyelectrolyte complexation. Physicochemical characterization pointed to the negatively charged particles with spherical morphology having a mean diameter less than 9 microm. Chitosan was localized dominantly in the particle wall, while for alginate, a homogeneous distribution… CONTINUE READING