Colocalization of multiple DNA loci: a physical mechanism.

  title={Colocalization of multiple DNA loci: a physical mechanism.},
  author={Valentino Bianco and Antonio Scialdone and Mario Nicodemi},
  journal={Biophysical journal},
  volume={103 10},
A variety of important cellular processes require, for functional purposes, the colocalization of multiple DNA loci at specific time points. In most cases, the physical mechanisms responsible for bringing them in close proximity are still elusive. Here we show that the interaction of DNA loci with a concentration of diffusing molecular factors can induce spontaneously their colocalization, through a mechanism based on a thermodynamic phase transition. We consider up to four DNA loci and… CONTINUE READING