Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes. Cholesterol depletion blocks insulin signalling for metabolic and mitogenic control.

@article{Karlsson2004ColocalizationOI,
  title={Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes. Cholesterol depletion blocks insulin signalling for metabolic and mitogenic control.},
  author={Margareta Karlsson and Hans Thorn and Anna Danielsson and Karin G. Stenkula and Anita Ost and Johanna Gustavsson and Fredrik H Nystrom and Peter Str{\aa}lfors},
  journal={European journal of biochemistry},
  year={2004},
  volume={271 12},
  pages={2471-9}
}
Caveolae are plasma membrane invaginations with several functions, one of which appears to be to organize receptor mediated signalling. Here we report that in primary human subcutaneous adipocytes the insulin receptor was localized to caveolae by electron microscopy/immunogold detection and by isolating caveolae from plasma membranes. Part of insulin receptor substrate 1 (IRS1), the immediate downstream signal mediator, was colocalized with the insulin receptor in the plasma membrane and… CONTINUE READING

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