Colocalization of dihydropyridine and ryanodine receptors in neonate rabbit heart using confocal microscopy.

  title={Colocalization of dihydropyridine and ryanodine receptors in neonate rabbit heart using confocal microscopy.},
  author={F. Sedarat and L. Xu and E. Moore and G. Tibbits},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={279 1},
  • F. Sedarat, L. Xu, +1 author G. Tibbits
  • Published 2000
  • Biology, Medicine
  • American journal of physiology. Heart and circulatory physiology
Because of undeveloped T tubules and sparse sarcoplasmic reticulum, Ca(2+)-induced Ca(2+) release (CICR) may not be the major mechanism providing contractile Ca(2+) in the neonatal heart. Spatial association of dihydropyridine receptors (DHPRs) and ryanodine receptors (RyRs), a key factor for CICR, was examined in isolated neonatal rabbit ventricular myocytes aged 3-20 days by double-labeling immunofluorescence and confocal microscopy. We found a significant increase (P < 0.0005) in the degree… Expand
77 Citations
Ca2+ sparks and cellular distribution of ryanodine receptors in developing cardiomyocytes from rat.
  • 13
Fetal and postnatal development of Ca2+ transients and Ca2+ sparks in rat cardiomyocytes.
  • 107
  • PDF
Ryanodine receptor function in newborn rat heart.
  • 34
  • PDF
Three-dimensional distribution of cardiac Na+-Ca2+ exchanger and ryanodine receptor during development.
  • 48
  • PDF
Ontogeny of Ca2+-induced Ca2+ release in rabbit ventricular myocytes.
  • 31
Localization and function of the Na+/Ca2+-exchanger in normal and detubulated rat cardiomyocytes.
  • 85
Na+/Ca2+ exchange activity in neonatal rabbit ventricular myocytes.
  • 44
Developmental changes of intracellular Ca2+ transients in beating rat hearts.
  • 79
  • PDF


Immunolocalization of sarcolemmal dihydropyridine receptor and sarcoplasmic reticular triadin and ryanodine receptor in rabbit ventricle and atrium
  • 279
  • Highly Influential
  • PDF
Isolation of the ryanodine receptor from cardiac sarcoplasmic reticulum and identity with the feet structures.
  • 297
Immunofluorescence localization of the Na-Ca exchanger in heart cells.
  • 120
Distribution of the Na+/Ca2+ exchange protein in developing rabbit myocytes.
  • 70
The Ca2+-release channel/ryanodine receptor is localized in junctional and corbular sarcoplasmic reticulum in cardiac muscle
  • 123
  • PDF
Developmental changes in myocardial mechanical function and subcellular organelles
  • 107
Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum.
  • A. Fabiato
  • Chemistry, Medicine
  • The American journal of physiology
  • 1983
  • 898
  • PDF
Na+/Ca2+ exchange current density in cardiac myocytes from rabbits and guinea pigs during postnatal development.
  • 81