Colocalization of dihydropyridine and ryanodine receptors in neonate rabbit heart using confocal microscopy.

@article{Sedarat2000ColocalizationOD,
  title={Colocalization of dihydropyridine and ryanodine receptors in neonate rabbit heart using confocal microscopy.},
  author={Franklin Sedarat and Liqun Xu and Edwin D. W. Moore and Glen F. Tibbits},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={279 1},
  pages={H202-9}
}
Because of undeveloped T tubules and sparse sarcoplasmic reticulum, Ca(2+)-induced Ca(2+) release (CICR) may not be the major mechanism providing contractile Ca(2+) in the neonatal heart. Spatial association of dihydropyridine receptors (DHPRs) and ryanodine receptors (RyRs), a key factor for CICR, was examined in isolated neonatal rabbit ventricular myocytes aged 3-20 days by double-labeling immunofluorescence and confocal microscopy. We found a significant increase (P < 0.0005) in the degree… CONTINUE READING

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