Colocalization of TGF-beta 1 and extracellular matrix proteins during rat tooth development.

@article{DSouza1992ColocalizationOT,
  title={Colocalization of TGF-beta 1 and extracellular matrix proteins during rat tooth development.},
  author={Rena N D'Souza and Kathleen C. Flanders and William T. Butler},
  journal={Proceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran toimituksia},
  year={1992},
  volume={88 Suppl 1},
  pages={419-26}
}
Recent studies suggest that TGF-beta 1 controls events in embryogenesis via its modulation of the extracellular matrix (ECM). During tooth development, histomorphogenetic and cytodifferentiation events are regulated by ECM-mediated epithelial-mesenchymal interactions. In this study, we have investigated the in vivo relationship of the localization of TGF-beta 1 to various ECM proteins, including glycosaminoglycans (GAGs), fibronectin, collagens I and III and to the enzyme alkaline phosphatase… CONTINUE READING