Colocalisation of predicted exonic splicing enhancers in BRCA2 with reported sequence variants

Abstract

Disruption of the breast cancer susceptibility gene BRCA2 is associated with increased risk of developing breast and ovarian cancer. Over 1800 sequence changes in BRCA2 have been reported, although for many the pathogenicity is unclear. Classifying these changes remains a challenge, as they may disrupt regulatory sequences as well as the primary protein… (More)
DOI: 10.1007/s10549-007-9714-5

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@article{Pettigrew2007ColocalisationOP, title={Colocalisation of predicted exonic splicing enhancers in BRCA2 with reported sequence variants}, author={Christopher A. Pettigrew and Nicola J Wayte and Ania Wronski and Paul K. Lovelock and Amanda B. Spurdle and Melissa Ann Brown}, journal={Breast Cancer Research and Treatment}, year={2007}, volume={110}, pages={227-234} }