Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery.

@article{Paciotti2004ColloidalGA,
  title={Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery.},
  author={Giulio F. Paciotti and L. Myer and David Weinreich and Dan V. Goia and Nicolae Pavel and Richard E. McLaughlin and Lawrence Rockville Tamarkin},
  journal={Drug delivery},
  year={2004},
  volume={11 3},
  pages={
          169-83
        }
}
Colloidal gold, a sol comprised of nanoparticles of Au(0), has been used as a therapeutic for the treatment of cancer as well as an indicator for immunodiagnostics. However, the use of these gold nanoparticles for in vivo drug delivery has never been described. This communication outlines the development of a colloidal gold (cAu) nanoparticle vector that targets the delivery of tumor necrosis factor (TNF) to a solid tumor growing in mice. The optimal vector, designated PT-cAu-TNF, consists of… CONTINUE READING

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