Colloidal behavior of proteins: effects of the second virial coefficient on solubility, crystallization and aggregation of proteins in aqueous solution.

@article{Valente2005ColloidalBO,
  title={Colloidal behavior of proteins: effects of the second virial coefficient on solubility, crystallization and aggregation of proteins in aqueous solution.},
  author={Joseph J Valente and Robert W. Payne and Mark Cornell Manning and William W. Wilson and Charles S Henry},
  journal={Current pharmaceutical biotechnology},
  year={2005},
  volume={6 6},
  pages={427-36}
}
There has been an increasing awareness that proteins, like other biopolymers, are large enough to exhibit colloidal behavior in aqueous solution. Net attractive or repulsive forces have been found to govern important physical properties, such as solubility and aggregation. The extent of intermolecular interactions, usually expressed in terms of the osmotic second virial coefficient, B, is most often measured using static light scattering. More recently, self-interaction chromatography (SIC) has… CONTINUE READING

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