Colloidal Au-enhanced surface plasmon resonance immunosensing.

  title={Colloidal Au-enhanced surface plasmon resonance immunosensing.},
  author={Lewis A Lyon and Mark D. Musick and Michael J. Natan},
  journal={Analytical chemistry},
  volume={70 24},
Surface plasmon resonance (SPR) biosensing using colloidal Au enhancement is reported. Immobilization of approximately 11-nm-diameter colloidal Au to an evaporated Au film results in a large shift in plasmon angle, a broadened plasmon resonance, and an increase in minimum reflectance. The incorporation of colloidal Au into SPR biosensing results in increased SPR sensitivity to protein-protein interactions when a Au film-immobilized antibody and an antigen-colloidal Au conjugate comprise the… CONTINUE READING


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