Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes.

@article{Helmrich2011CollisionsBR,
  title={Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes.},
  author={Anne Helmrich and Monica Ballarino and L{\'a}szl{\'o} Tora},
  journal={Molecular cell},
  year={2011},
  volume={44 6},
  pages={966-77}
}
We show that the time required to transcribe human genes larger than 800 kb spans more than one complete cell cycle, while their transcription speed equals that of smaller genes. Independently of their expression status, we find the long genes to replicate late. Regions of concomitant transcription and replication in late S phase exhibit DNA break hot spots known as common fragile sites (CFSs). This CFS instability depends on the expression of the underlying long genes. We show that RNA:DNA… CONTINUE READING
Highly Influential
This paper has highly influenced 24 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 6 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 164 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 65 references

Molecular Cell Replication/Pol II Collisions Cause

  • J. Breakage Singh, R. A. Padgett
  • Nat. Struct. Mol. Biol
  • 2009
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…