Collision-induced dissociation (CID) of peptides and proteins.

  title={Collision-induced dissociation (CID) of peptides and proteins.},
  author={J Mitchell Wells and Scott A McLuckey},
  journal={Methods in enzymology},
The most commonly used activation method in the tandem mass spectrometry (MS) of peptides and proteins is energetic collisions with a neutral target gas. The overall process of collisional activation followed by fragmentation of the ion is commonly referred to as collision-induced dissociation (CID). The structural information that results from CID of a peptide or protein ion is highly dependent on the conditions used to effect CID. These include, for example, the relative translational energy… CONTINUE READING
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