Collinear Hox-Hox interactions are involved in patterning the vertebrate anteroposterior (A-P) axis

@inproceedings{Zhu2017CollinearHI,
  title={Collinear Hox-Hox interactions are involved in patterning the vertebrate anteroposterior (A-P) axis},
  author={Kongju Zhu and Herman P. Spaink and Antony J Durston},
  booktitle={PloS one},
  year={2017}
}
Investigating regulation and function of the Hox genes, key regulators of positional identity in the embryo, opened a new vista in developmental biology. One of their most striking features is collinearity: the temporal and spatial orders of expression of these clustered genes each match their 3' to 5' order on the chromosome. Despite recent progress, the mechanisms underlying collinearity are not understood. Here we show that ectopic expression of 4 different single Hox genes predictably… CONTINUE READING
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