Colletoic Acid, a Novel 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor from Colletotrichum gloeosporioides SANK 21404

@article{Aoyagi2008ColletoicAA,
  title={Colletoic Acid, a Novel 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor from Colletotrichum gloeosporioides SANK 21404},
  author={Azusa Aoyagi and Mariko Ito-Kobayashi and Y. Ono and Y. Furukawa and M. Takahashi and Y. Muramatsu and Megumi Umetani and T. Takatsu},
  journal={The Journal of Antibiotics},
  year={2008},
  volume={61},
  pages={136-141}
}
  • Azusa Aoyagi, Mariko Ito-Kobayashi, +5 authors T. Takatsu
  • Published 2008
  • Biology, Medicine
  • The Journal of Antibiotics
  • Colletoic acid, a novel 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, was found and isolated from the cultured broth of the producing fungus Colletotrichum gloeosporioides SANK 21404. Its structure was determined to be a novel acorene-type sesquiterpene by several spectroscopic methods. The absolute structure of colletoic acid was established using a modified Mosher's method and single-crystal X-ray diffraction analysis. 
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