Collective cell migration in morphogenesis, regeneration and cancer

  title={Collective cell migration in morphogenesis, regeneration and cancer},
  author={Peter Friedl and Darren Gilmour},
  journal={Nature Reviews Molecular Cell Biology},
The collective migration of cells as a cohesive group is a hallmark of the tissue remodelling events that underlie embryonic morphogenesis, wound repair and cancer invasion. In such migration, cells move as sheets, strands, clusters or ducts rather than individually, and use similar actin- and myosin-mediated protrusions and guidance by extrinsic chemotactic and mechanical cues as used by single migratory cells. However, cadherin-based junctions between cells additionally maintain… CONTINUE READING
Highly Influential
This paper has highly influenced 39 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper


Publications citing this paper.
Showing 1-10 of 699 extracted citations

Cell-Cell Contact and Receptor Tyrosine Kinase Signaling.

Cold Spring Harbor perspectives in biology • 2018
View 4 Excerpts
Highly Influenced

Systems Biology of Tumor Microenvironment

Advances in Experimental Medicine and Biology • 2016
View 6 Excerpts
Highly Influenced

The Cohesive Metastasis Phenotype in Human Prostate Cancer.

Biochimica et biophysica acta • 2016
View 8 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 134 references

Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma

R Massoumi
J. Exp. Med • 2009

Similar Papers

Loading similar papers…