Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion.

@article{Wall2008CollectiveAI,
  title={Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion.},
  author={Esther van de Wall and Rebecca L. Leshan and Allison Wanting Xu and Nina Balthasar and Roberto Coppari and Shun Liu and Young Hwan Jo and Robert G Mackenzie and David B. Allison and Nae J. Dun and Joel K Elmquist and Bradford B. Lowell and Gregory S Barsh and Carl de Luca and Martin G Myers and Gary J Schwartz and Streamson C. Chua},
  journal={Endocrinology},
  year={2008},
  volume={149 4},
  pages={1773-85}
}
Two known types of leptin-responsive neurons reside within the arcuate nucleus: the agouti gene-related peptide (AgRP)/neuropeptide Y (NPY) neuron and the proopiomelanocortin (POMC) neuron. By deleting the leptin receptor gene (Lepr) specifically in AgRP/NPY and/or POMC neurons of mice, we examined the several and combined contributions of these neurons to leptin action. Body weight and adiposity were increased by Lepr deletion from AgRP and POMC neurons individually, and simultaneous deletion… CONTINUE READING

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