• Corpus ID: 220665716

Collective Motility, Mechanical Waves, and Durotaxis in Cell Clusters

  title={Collective Motility, Mechanical Waves, and Durotaxis in Cell Clusters},
  author={Youyuan Deng and Herbert Levine and Xiaoming Mao and Leonard M. Sander},
  journal={arXiv: Biological Physics},
When epithelial cell clusters move in a collective manner on a substrate mechanical signals play a major role in organizing the coherent behavior. There are a number of unexplained experimental results from traction force microscopy for a system of this type (MDCK cell clusters). These include: the internal strains are tensile even for clusters that expand by proliferation; the tractions on the substrate are confined to the edges of the cluster; in many cases there are density waves within the… 
3 Citations

Figures and Tables from this paper

Stiffness-dependent active wetting enables optimal collective cell durotaxis

This study demonstrates a physical mechanism of collective durotaxis, through both cell-cell and cell-substrate adhesion ligands, based on the wetting properties of active droplets based on a balance between in-plane active traction and tissue contractility, and out-of-plane surface tension.

Collective durotaxis of cohesive cell clusters on a stiffness gradient

This work theoretically analyze a continuum active polar fluid model that has been tested in recent wetting assays of epithelial tissues and includes two types of active forces, and shows that this model generically predicts collective durotaxis, and that it features a variety of dynamical regimes as a result of the interplay between the spreading state and the global propagation.

Activity waves and freestanding vortices in populations of subcritical Quincke rollers

It is demonstrated that systems in which isolated but potentially active particles do not move can exhibit specific and remarkable collective properties, and it is argued that a faithful description of the collective properties of Quincke rollers need to consider the fluid surrounding particles.



Mechanical waves during tissue

  • expansion. Nat. Phys. 8,
  • 2012

The role of single-cell mechanical behaviour and polarity in driving collective cell migration

It is shown that collective movements of epithelial cells can be triggered by polarity signals at the single-cell level through the establishment of coordinated lamellipodial protrusions and demonstrate that collective cell dynamics in closed environments as observed in multiple in vitro and in vivo situations can arise from single- cell behaviour through a sustained memory of cell polarity.

Leader-cell-driven epithelial sheet fingering

A subcellular-element-based model of this fingering instability, which incorporates leader cells and other related properties of a monolayer of epithelial cells, and shows that in this model no finger protrusions would emerge in a phenotypically homogenous active fluid.

Cell motility, contact guidance, and durotaxis.

A simple mechanical model for cell migration coupled to substrate properties, by placing a simulated cell on a lattice mimicking biopolymer gels or hydrogels, is presented, able to reproduce both contact guidance and durotaxis.

Mesoscale physical principles of collective cell organization

We review recent evidence showing that cell and tissue dynamics are governed by mesoscale physical principles. These principles can be understood in terms of simple state diagrams in which control

Hydrodynamics of soft active matter

This review summarizes theoretical progress in the field of active matter, placing it in the context of recent experiments, and highlights the experimental relevance of various semimicroscopic derivations of the continuum theory for describing bacterial swarms and suspensions, the cytoskeleton of living cells, and vibrated granular material.

Active Fingering Instability in Tissue Spreading.

Overall, it is shown that spreading epithelia experience an active fingering instability based on a simple kinematic mechanism, which underscores the crucial role of long-range hydrodynamic interactions in the dynamics of tissue morphology.

Mechanical waves during tissue expansion

Innovative experiments reveal the origin of gradients in tension established through intercellular forces in a mechanical wave set up by sequential cell reinforcement and fluidization in tissue growth and regrowth.

Stability and Roughness of Interfaces in Mechanically Regulated Tissues.

The fluctuations of a stable interface subjected to cell-level stochasticity are analyzed, and it is found that mechanical feedback can help preserve reproducibility at the tissue scale.

Role of the supracellular actomyosin cable during epithelial wound healing.

A particle-based model that includes purse-string contraction, cell crawling and other properties incorporated with monolayers of Madin-Darby canine kidney (MDCK) cells is developed and it is shown that patterns of traction force pointing towards the wound are induced by the purse- string contraction.