Collection and expansion of single cells and colonies released from a micropallet array.

@article{Wang2007CollectionAE,
  title={Collection and expansion of single cells and colonies released from a micropallet array.},
  author={Yuli Wang and Grace T Young and Mark Bachman and Christopher Eldridge Sims and G. P. Li and Nancy L Allbritton},
  journal={Analytical chemistry},
  year={2007},
  volume={79 6},
  pages={2359-66}
}
The ability to selectively grow out individual cells possessing unique characteristics from within a mixed population is of widespread importance for biomedical investigations. Generation of genetically engineered cell lines, transformation studies, cell-based assays, and stem cell studies are examples where single-cell cloning is of immense value. The vast majority of mammalian cells grow adherent to a surface; therefore, positive selection followed by cloning of cells while the cells remain… CONTINUE READING