Collecting duct carcinomas of the kidney: a comparative loss of heterozygosity study with clear cell renal cell carcinoma.

@article{Fogt1998CollectingDC,
  title={Collecting duct carcinomas of the kidney: a comparative loss of heterozygosity study with clear cell renal cell carcinoma.},
  author={Franz Fogt and Zhengping Zhuang and W. Marston Linehan and Mar{\'i}a Jos{\'e} Beato Merino},
  journal={Oncology reports},
  year={1998},
  volume={5 4},
  pages={923-6}
}
Origin of collecting duct carcinomas (CDC) of the kidney is not entirely known, although it is thought that they originate from the distal collecting duct system, whereas clear cell renal cell carcinoma (cRCC) may originate from the proximal tubular epithelium. In cRCC, the von Hippel Lindau gene (vHL) is damaged in almost 100% of cases; the frequency of vHL deletions in CDC is not known. Loss of heterozygosity (LOH) of CDC and cRCC of vHL (3p), p16 (9p), p53 (17p) and the retinoblastoma (RB… CONTINUE READING