Collateral projections from striatonigral neurons to substance P receptor-expressing intrinsic neurons in the striatum of the rat.

@article{Lee1997CollateralPF,
  title={Collateral projections from striatonigral neurons to substance P receptor-expressing intrinsic neurons in the striatum of the rat.},
  author={T Lee and Takeshi Kaneko and Ryuichi Shigemoto and Sakashi Nomura and Noboru Mizuno},
  journal={The Journal of comparative neurology},
  year={1997},
  volume={388 2},
  pages={250-64}
}
It is well known that striatonigral neurons produce substance P (SP); however, no SP receptor (SPR) has so far been found in the substantia nigra. On the other hand, a previous study in the rat striatum indicated that SPR was expressed only in cholinergic or somatostatinergic intrinsic neurons (Kaneko et al. [1993] Brain Res. 631:297-303). Thus, it was assumed that SP produced by striatonigral neurons might be released through their intrastriatal axon collaterals to act upon intrinsic neurons… CONTINUE READING

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