Collateral Lethality: A new therapeutic strategy in oncology.

@article{Muller2015CollateralLA,
  title={Collateral Lethality: A new therapeutic strategy in oncology.},
  author={Florian Muller and Elisa A Aquilanti and Ronald A. Depinho},
  journal={Trends in cancer},
  year={2015},
  volume={1 3},
  pages={161-173}
}
Genomic deletion of tumor suppressor genes (TSG) is a rite of passage for virtually all human cancers. The synthetic lethal paradigm has provided a framework for the development of molecular targeted therapeutics that are functionally linked to the loss of specific TSG functions. In the course of genomic events that delete TSGs, a large number of genes with no apparent direct role in tumor promotion also sustain deletion as a result of chromosomal proximity to the target TSG. In this… CONTINUE READING
Highly Cited
This paper has 52 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 34 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.

53 Citations

0204060201620172018
Citations per Year
Semantic Scholar estimates that this publication has 53 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…