Collapsing SNP genotypes in case-control genome-wide association studies increases the type I error rate and power.

@article{Matthews2008CollapsingSG,
  title={Collapsing SNP genotypes in case-control genome-wide association studies increases the type I error rate and power.},
  author={Abigail Matthews and Chad Haynes and Chang Zhen Liu and J{\"u}rg Ott},
  journal={Statistical applications in genetics and molecular biology},
  year={2008},
  volume={7 1},
  pages={
          Article23
        }
}
Genome-wide association studies are now widely used tools to identify genes and/or regions which may contribute to the development of various diseases. With case-control data a 2x3 contingency table can be constructed for each SNP to perform genotype-based tests of association. An increasingly common technique to increase the power to detect an association is to collapse each 2x3 table into a table assuming either a dominant or recessive mode of inheritance (2x2 table). We consider three… CONTINUE READING
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