Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity.

  title={Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity.},
  author={Young Chan Chae and Sukmook Lee and Kyun Heo and Sang Hoon Ha and Yonwoo Jung and Jong Hyun Kim and Yasuo Ihara and Pann Ghill Suh and Sung Ho Ryu},
  journal={Cellular signalling},
  volume={21 12},
Collapsin response mediator protein-2 (CRMP-2) plays a key role in axonal development by regulating microtubule dynamics. However, the molecular mechanisms underlying this function have not been clearly elucidated. In this study, we demonstrated that hCRMP-2, specifically amino acid residues 480-509, is essential for stimulating tubulin GTPase activity. We also found that the GTPase-activating protein (GAP) activity of hCRMP-2 was important for microtubule assembly and neurite formation in… CONTINUE READING


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