Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33

@article{Goshima1995CollapsininducedGC,
  title={Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33},
  author={Yoshio Goshima and Fumio Nakamura and Philipp Strittmatter and Stephen M Strittmatter},
  journal={Nature},
  year={1995},
  volume={376},
  pages={509-514}
}
COLLAPSIN1, a member of the newly recognized semaphorin family2á¤-4, contributes to axonal pathfinding during neural development by inhibiting growth cone extension1á¤-5. The mechanism of collapsin action is poorly understood. Here we use a Xenopus laevis oocyte expression system to identify molecules involved in collapsin signalling, because several experiments have raised the possibility that heterotrimeric GTP-binding proteins might participate in these events6á¤-9. A collapsin response… CONTINUE READING
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