Collapsin: A protein in brain that induces the collapse and paralysis of neuronal growth cones

@article{Luo1993CollapsinAP,
  title={Collapsin: A protein in brain that induces the collapse and paralysis of neuronal growth cones},
  author={Y. Luo and D. Raible and J. Raper},
  journal={Cell},
  year={1993},
  volume={75},
  pages={217-227}
}
Repulsive guidance cues can steer neuronal growth cones during development and prevent mature axons from regenerating. We have identified a 100 kd glycoprotein in the chick brain that is a good candidate for a repulsive cue. Since it induces the collapse and paralysis of neuronal growth cones in vitro, we have named it collapsin. It is effective at concentrations of approximately 10 pM. The C-terminal half of collapsin contains a single immunoglobulin-like domain and an additional highly basic… Expand
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4
5
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References

SHOWING 1-10 OF 53 REFERENCES
Oligodendrocytes repel axons and cause axonal growth cone collapse.
  • 127
Oligodendrocytes arrest neurite growth by contact inhibition
  • 288
  • PDF
...
1
2
3
4
5
...