Collapse of DNA in packaging and cellular transport.

@article{Thomas2018CollapseOD,
  title={Collapse of DNA in packaging and cellular transport.},
  author={T J Thomas},
  journal={International journal of biological macromolecules},
  year={2018},
  volume={109},
  pages={
          36-48
        }
}
The dawn of molecular biology and recombinant DNA technology arose from our ability to manipulate DNA, including the process of collapse of long extended DNA molecules into nanoparticles of approximately 100 nm diameter. This condensation process is important for the packaging of DNA in the cell and for transporting DNA through the cell membrane for gene therapy. Multivalent cations, such as natural polyamines (spermidine and spermine), were initially recognized for their ability to provoke DNA… CONTINUE READING
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