Collagenous colitis: Histologic, morphometric, immunohistochemical and ultrastructural studies. Report of 21 cases

@article{Widgren1988CollagenousCH,
  title={Collagenous colitis: Histologic, morphometric, immunohistochemical and ultrastructural studies. Report of 21 cases},
  author={Sven Widgren and Rachid Jlidi and Jeremiah Cox},
  journal={Virchows Archiv A},
  year={1988},
  volume={413},
  pages={287-296}
}
We examined 129 colonic biopsies from 21 patients with collagenous colitis, most of whom presented with diarrhoea. Morphometric measurements gave a mean thickness of the subepithelial collagen deposit of 19.5 µ ± 5.1. The trapped fusiform and/or stellate cells within the deposits were identified immunohistochemically as myoid cells, being positive with antibody against smooth muscle cell alpha-actin. Ultrastructurally, these cells have all the characteristic features of myofibroblasts. Similar… CONTINUE READING
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