Collagenases and cracks in the plaque.

@article{Libby2013CollagenasesAC,
  title={Collagenases and cracks in the plaque.},
  author={Peter Libby},
  journal={The Journal of clinical investigation},
  year={2013},
  volume={123 8},
  pages={3201-3}
}
The core of an atheromatous plaque contains lipids, macrophages, and cellular debris, typically covered by a fibrous cap that separates the thrombogenic core from the blood. Rupture of the fibrous cap causes most fatal myocardial infarctions. Interstitial collagen confers tensile strength on the cap, as it does in skin and tendons. In 1994, Peter Libby and colleagues demonstrated overexpression of collagenolytic enzymes in atheromatous plaques and implicated MMPs in the destabilization of these… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
30 Citations
26 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Genetically engineered collagenase resistance promotes abdominal aortic aneurysm formation

  • J Deguchi
  • Lab Invest
  • 2009

Similar Papers

Loading similar papers…