Collagenase synthesis of rheumatoid arthritis synoviocytes: dose-dependent stimulation by substance P and capsaicin.
@article{Partsch1991CollagenaseSO, title={Collagenase synthesis of rheumatoid arthritis synoviocytes: dose-dependent stimulation by substance P and capsaicin.}, author={Gerald Partsch and Marco Matucci-Cerinic and Simone Marabini and Susanne Jantsch and Alberto Moggi Pignone and Mario Cagnoni}, journal={Scandinavian journal of rheumatology}, year={1991}, volume={20 2}, pages={ 98-103 } }
The synthesis and release of collagenase in the presence of the neuropeptide substance P (SP) and capsaicin, were investigated in vitro using identical synoviocyte cultures from patients with rheumatoid arthritis (RA). On average 10(-12) M SP augmented statistically significantly the collagenase production by approximately a factor of five. An increase in the concentrations up to 10(-6) M SP resulted in a decreased collagenase synthesis, which, however, was still above the level of that of the…
21 Citations
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