Collagenase synthesis of rheumatoid arthritis synoviocytes: dose-dependent stimulation by substance P and capsaicin.

@article{Partsch1991CollagenaseSO,
  title={Collagenase synthesis of rheumatoid arthritis synoviocytes: dose-dependent stimulation by substance P and capsaicin.},
  author={Gerald Partsch and Marco Matucci-Cerinic and Simone Marabini and Susanne Jantsch and Alberto Moggi Pignone and Mario Cagnoni},
  journal={Scandinavian journal of rheumatology},
  year={1991},
  volume={20 2},
  pages={
          98-103
        }
}
The synthesis and release of collagenase in the presence of the neuropeptide substance P (SP) and capsaicin, were investigated in vitro using identical synoviocyte cultures from patients with rheumatoid arthritis (RA). On average 10(-12) M SP augmented statistically significantly the collagenase production by approximately a factor of five. An increase in the concentrations up to 10(-6) M SP resulted in a decreased collagenase synthesis, which, however, was still above the level of that of the… 
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21 Citations
Background Citations
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Methods Citations
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Results Citations
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21 Citations

Capsaicin stimulates the migration of human polymorphonuclear cells (PMN) in vitro.

Substance P Induces the Secretion of Gelatinase A from Human Synovial Fibroblasts

It is assumed that distinct stimulation pathways are involved and that the neuropeptide (substance P), which is always present in the inflamed joint, plays its own and separate role in proliferative processes leading to the cartilage destruction.

Experimental Models of Arthritis: Identification of Substance P as a Therapeutic Target and Use of Capsaicin to Manage Joint Pain and Inflammation

Effect of substance P and somatostatin on migration of polymorphonuclear (PMN) cells in vitro

Although it is uncertain whether in vivo SP and SOM contribute directly to the invasion of PMN cells into the joint cavity, the influence of these neuropeptides on PMN migration in vitro is a further indication of the neuropeptic involvement in the genesis of inflammation.

Effects of adjuvant on neuropeptide-like immunoreactivity in experimentally induced temporomandibular arthritis in rats.

SUBSTANCE P UP-REGULATES MATRIX METALLOPROTEINASE-1 AND DOWN-REGULATES COLLAGEN IN HUMAN LUNG FIBROBLAST

Results suggest that substance P participates in extracellular matrix metabolism, and induced a decrease in collagen biosynthesis, concomitant to a down-regulation of pro-α1(I) collagen mRNA.

Is the pretreatment effect of low dose Freund's adjuvant on adjuvant arthritis due to an activation of the nervous system?

Tachykinin receptor modulators: novel therapeutics for rheumatoid arthritis.

  • Brunelleschi
  • Biology, Medicine
    Expert opinion on investigational drugs
  • 1999
Different observations suggest that one approach to the treatment of RA might be to inhibit the local effects of neurokinins in the affected joints, and this review will summarise the more relevant aspects of this topic.

Plasminogen activators and plasminogen activator inhibitors in connective tissues and connective tissue cells: influence of the neuropeptide substance P on expression.

Microscopic localization of active gelatinases in equine osteochondritis dissecans (OCD) cartilage.

Investigating the relationship between matrix metalloproteinase (MMP) activity and osteochondritis dissecans (OCD) in the equine joint revealed MMP activity, especially in the deep zone adjacent to the calcified subchondral bone.

References

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