Collagenase nanocapsules: An approach to fibrosis treatment.

  title={Collagenase nanocapsules: An approach to fibrosis treatment.},
  author={Mar{\'i}a Roc{\'i}o Villegas and Alejandro Baeza and Alicia Usategui and Pablo Luis Ortiz-Romero and Jos{\'e} Luis Pablos and Mar{\'i}a Vallet‐Reg{\'i}},
  journal={Acta biomaterialia},

UVA-Degradable Collagenase Nanocapsules as a Potential Treatment for Fibrotic Diseases

A novel methodology for the preparation of collagenase nanocapsules without affecting its enzymatic activity and capable of releasing the enzyme in response to an ultraviolet A (UVA) light stimulus is presented.

Sixty years in the making: collagenase Clostridium histolyticum, from benchtop to FDA approval and beyond

The development of CCH in the treatment of PD is traced from the earliest in vitro investigations to comprehensive multi-study meta-analyses confirming its highly rated efficacy when compared to other historical non-surgical remedies.

Current role of the collagenase Clostridium histolyticum in Dupuytren’s disease treatment

The administration of this treatment is promising although long-term studies are necessary to see the real role that this drug can play in both Dupuytren’s disease and other fibrotic disorders.

Pathological mechanisms and therapeutic outlooks for arthrofibrosis

The researchers propose the existence of two subtypes of arthrofibrosis—one involving active scar formation, and one in which inflammatory processes have resolved—and they suggest each should be treated differently.

The Role of Transmission Electron Microscopy in the Early Development of Mesoporous Materials for Tissue Regeneration and Drug Delivery Applications

The present paper shows the role of transmission electron microscopy and associated spectroscopic techniques in the search for useful information in the early design stages of mesoporous systems, with application in the fields of tissue regeneration and drug delivery systems.

Anti-small cell lung cancer and collagenase inhibition properties of Hydroxysafflor yellow A

Maybe the anti-human lung carcinoma properties of the recent molecule are related to their antioxidant effects.

Comparison of Primary Keloid Fibroblast Cultivation Methods and the Characteristics of Fibroblasts Cultured from Keloids, Keloid-surrounding Tissues, and Normal Skin Tissues

Real-time PCR results showed that the mRNA expression levels of keloid-related genes in cultured fibroblasts c or elated to their in vivo expression profile, as previously reported in other studies.


The results showed the advantage of this semipurification technique as concerns to the low cost of extraction and purification, adding value to the fishing source material and allocating the residues from its processing to the industry.

Therapeutic and diagnostic targeting of fibrosis in metabolic, proliferative and viral disorders.



Hybrid Collagenase Nanocapsules for Enhanced Nanocarrier Penetration in Tumoral Tissues.

A novel nanodevice able to transport proteolytic enzymes coated with an engineered pH-responsive polymeric that can improve the therapeutic efficacy of the current nanomedicines, allowing a more homogeneous and deeper distribution of the therapeutic nanosystems in cancerous tissues.

Collagenase Followed by Compression for the Treatment of Earlobe Keloids

Intralesional collagenase followed by compression appears to be a safe and modestly effective treatment for earlobe keloids, and warrants further investigation in larger studies with longer follow-up in motivated patients who decline surgical excision.

The emerging role of Clostridium histolyticum collagenase in the treatment of Dupuytren disease

Clostridial collagenase is a novel nonsurgical treatment option of considerable potential in the management of DD when administered by specialist hand surgeons with detailed knowledge of the disease and the relevant anatomy, but there is a need for further data on long-term results, complications, and rate of recurrence with the use of this emerging treatment option.

Intra-lesional injections of collagenase are ineffective in the treatment of keloid and hypertrophic scars.

Collagenase clostridium histolyticum in Dupuytren's contracture: a systematic review.

The use of collagenase clostridium histolyticum provides better outcomes in patients with mild-moderate joint contracture, with lower complications and side effects than open fasciectomy, with shorter recovery time and the low incidence of serious or major adverse effects.

Current and emerging treatment options for Peyronie’s disease

A surgical approach should be considered when men with PD do not respond to conservative, medical, or minimally invasive therapies for approximately 1 year and cannot have satisfactory sexual intercourse, and novel treatments for the many men suffering with PD are anticipated.

Surgical correction of persistent Peyronie's disease following collagenase clostridium histolyticum treatment.

This initial case series supports the hypothesis that prior CCH treatment is not a contraindication to PEG or TAP surgery in the treatment of penile curvature in patients with PD.

Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector.

Fibrillar collagen can be a formidable barrier to viral distribution and matrix-modifying treatments can significantly enhance the therapeutic response, resulting in an extended range of infected tumor cells and improved virus propagation, ultimately leading to enhanced therapeutic outcome.

Collagenase clostridium histolyticum intralesional injections for the treatment of Peyronie’s disease: a safety profile

Non-surgical and surgical management options exist, with surgery often being offered in the most severe cases, and surgery carries the potential morbidity of penile shortening, neurovascular injury and erectile dysfunction.