Collagenase-induced intracerebral hemorrhage in rats.

  title={Collagenase-induced intracerebral hemorrhage in rats.},
  author={Gary A Rosenberg and Sheila Mun-Bryce and Margaret W. Wesley and Mario Kornfeld},
  volume={21 5},
Intracranial bleeding is an important cause of brain masses and edema. To study the pathophysiology of intracerebral hemorrhage, we produced experimental hemorrhages in 53 rats and characterized the lesion by histology, brain water content, and behavior. Adult rats had 2 microliters saline containing 0.5 unit bacterial collagenase infused into the left caudate nucleus. Histologically, erythrocytes were seen around blood vessels at the needle puncture site within the first hour. By 4 hours there… CONTINUE READING
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