Collagenase expression in transgenic mouse skin causes hyperkeratosis and acanthosis and increases susceptibility to tumorigenesis.

@article{Darmiento1995CollagenaseEI,
  title={Collagenase expression in transgenic mouse skin causes hyperkeratosis and acanthosis and increases susceptibility to tumorigenesis.},
  author={Jeanine M D'armiento and Teresa DiColandrea and Seema S. Dalal and Yuki Okada and M T Huang and Allan H. Conney and Kiran K Chada},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 10},
  pages={5732-9}
}
In a series of transgenic mice, the human tissue collagenase gene was expressed in the suprabasal layer of the skin epidermis. Visually, the mice had dry and scaly skin which upon histological analysis revealed acanthosis, hyperkeratosis, and epidermal hyperplasia. At the ultrastructural level, intercellular granular materials were absent in the transgenic skin epidermis but contact was maintained through the intact desmosomes. Despite a diversity of underlying etiologies, similar morphological… CONTINUE READING
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The collagens: biochemistry and pathophysiology

  • E. Kucharz
  • 1992

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